pentobarbital will lessen the level or effect of abemaciclib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of abemaciclib with powerful CYP3A4 inducers decreases plasma focus of abemaciclib and its metabolites.Warning is warranted for individuals with renal and hepatic impairment. Although t